Protoform, Inc.

Formulation Equipment

Tablets/ Capsules

  • Instrumented tablet press (Riva model Piccola 10 station B-type) - Capable of measuring main compression force, pre-compression force and ejection force
  • Digital calipers
  • Hardness tester (Key model HT-500)
  • Friability tester (Key model FT-400)
  • Disintegration tester (GlobePharma ELECTOLAB model ED-2L)
  • Capsule filler (Tarpac)
  • Carver press (Model 3851-0)
  • Magnum Tablet Press (model D-23)

Coating and Drying

  • Fluid bed (Mendel model FBP-1) – Capable of processing 0.2 – 3 kg with top spray, bottom spray and Wurster column
  • Extruder Spheronizer (Mendel model MES-350)
  • Drying oven (Lindberg/Blue Model MO1450 GPAA-1)

Granulation

  • High sheer granulator - (Mini-MGT Nr. 93.06) Bowl sizes: 0.25, 0.5, 1, and 4L
  • Moisture analyzer (Denver Instruments model IR30

Powder Analysis

  • Flodex powder flow tester (Hanson 21-101-050)
  • Bulk density tester (Scott Volumeter)
  • Tap density tester (GlobePharma model EDT-1020)
  • AutoSiever (Gilson) - Sieve sizes: US-std. 16, 18, 20, 30, 40, 60, 80, 100, 120, 140, 170, 200, 325 and 500
  • Precision sieve sizes: 10μ, 20μ, 30μ, 40μ, 60μ, and 80μ
  • Steel sieves (8”) - Sizes: US-std. 12, 18, 20, 30, 35, 40, 45, 50, 60, 70, 80, 100, 120, 140, 170, 200
  • Tyler Ro-Top Test Sieve Shaker/fractionator (model Rx 29-E)

Size Reduction

  • Comminuting mill (Quadro model U5-0371) –speeds 1000 to 6500 RPM Round hole screen sizes (inches): 0.020, 0.033, 0.065, 0.093, 0.109, 0.125, and 0.156
  • Fitz Mill (model L-1-A perforated screen sizes 0.5mm to 3.96mm)
  • Frewitt Ocillating Mill (model GLT-001) Screen sizes 18, 20, 30, 40, 50, and 60 mesh

Blending / Mixing

  • Twin shell blender - Shell sizes: 1, 2, 4, and 8qt.
  • Twin Shell blender 5 cu. Ft. (Patterson-Kelly model number 230796)
  • Twin Shell blender 20 cu. Ft. (Patterson-Kelly model number 189071)
  • Turbula Shaker-Mixer (Model T2C Numb. 890176) – Capacity: 5 – 2,000mL
  • Homogenizer - Stator volume range: 50 – 2,500mL
  • Digital Overhead Stirrers

Top Load Balances:

  • Mettler models: PM 200, PM 400, AE200
  • Sartorius models: U 4100 S, CP225D, w/printer
  • Denver Instruments model XP 1500
  • Ohaus model CD-11
  • Uline model H-670

Analytical Equipment

Chromotography

Chromatography

  • HPLC System No. 1 (Hewlett Packard model 1050 with ChemStation version A.09.00) - Equipped with a 100 vial tray autosampler, quaternary pump, column heater, and 1100 series variable wavelength detector
  • HPLC System No. 2 (Hewlett Packard model 1050 with ChemStation version A.09.00) - Equipped with a 100 vial tray autosampler, quaternary pump, column heater, diode array detector and 1047A refractive index detector
  • HPLC System No. 3 (Hewlett Packard model 1050 with ChemStation version A.09.00) - Equipped with a 100 vial tray autosampler, quaternary pump, column heater, and variable wavelength detector
Dissolution Bath

Dissolution

  • Dissolution System (Distek model 2100A) – Equipped with apparatus 1 or 2 and 900 mL standard or amber vessels, Hewlett Packard spectrophotometer (model 8453) with ChemStation version A.10.01, Vankel Autosampler (model VK 8000)
  • Dissolution System (VanKel model VK 7000) – Equipped with apparatus 1 or 2 and 900 mL standard or amber vessels, Hewlett Packard spectrophotometer (model 8453) with ChemStation version A.10.01, Vankel Autosampler (model VK 8000)
Aquire Data

Karl Fischer

  • Coulometer (Brinkmann model 831 KF)

Stability Equipment

  • Chamber No. 1 (Darwin Chambers model PH) - 25ºC 60% RH
  • Chamber No. 2 (Darwin Chambers model PH) - 40ºC 75% RH
  • Bottle cap induction sealer (Enercon model Super Seal Jr.)

Accessories

  • Class A glassware
  • Water purification system (Barnstead model E-Pure)
  • Heating Bath/Circulator (Neslab model RTE 7)
  • Wrist action shaker (Burrell model 75)
  • pH meter (Denver model Ultra Basic)
  • Microscope 40x, 100x, 400x and 1000x (AmScope model 120) – Equipped with digital camera and image software
  • Microscope 15x and 30x (Fisher Scientific model Stereomaster)
  • Oven (Fisher Scientific model Isotemp)
  • Table-top centrifuge (eppendorf model 5415)
  • Sonicators (Branson models: 1210 and 2200)
  • Sonicator (Fisher Scientific ULTRASONIC BATH 20.8L)
  • Vacuum-Pressure pump (Millipore)
  • Stir-Hotplates (Corning models PC-351 and PC-520)
  • Digital Stir-Hotplates (Fisher Scientific model IsoTemp)
  • Viscometer (Brookfield Model DV-E)
  • Vortex Genie2
  • Multi-Tube vortexer (Baxter)
  • Test-tube temp-blocks (Lab-Line Instruments)
  • Desiccator cabinets
  • Refrigerator
  • Pipetters (Fisher Scientific models Finnpipette)
    • Volume ranges: 0.5 -10 μL, 20 -200 μL, 100 -1,000 μL, and 2,000 – 10,000 μL
  • Pipetter (Eppendorf Series 2100)
    • Volume range: 500 -5,000 μL
  • Repeater pipetter (Eppendorf)
      Volume ranges: 25 -125 μL, and 250 -1250 μL
  • Pipet pumps
    • Volumes: 2, 10, and 25 mL